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Once PRR is activated, it interacts with ASC, recruits and activates procaspase-1 to cleave and produce the active caspase-1, which then catalyzes the generation of the key pyroptosis-inducing protein GSDMD-NT and active inflammatory factors, leading to cell membrane perforation, cytoplasmic content leakage, and triggering a cascade of inflammatory responses [112, 113]

Ghrelin receptor activation in the ventral tegmental area amplified instrumental responding but not the excitatory influence of Pavlovian stimuli on instrumental responding

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DISCLOSURES: The authors declare no conflicts of interest relevant to the content of this article